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Main Goal

To advance scientific knowledge on the use of remineralization strategies for repair and preservation of tooth structure.

Specific Goals

  • To develop and evaluate new approaches of enhancing the remineralization of enamel and dentin
  • To develop new remineralization models and validate existing and new models
Program Director (Interim)  

Dr. Anderson T. Hara

Other Faculty Supporting the Program

Dr. Domenick T. Zero

Relevant Publications

Zero DT, Zhang JZ, Harper DS, Wu M, Kelly S, Waskow J, Hoffman M. The remineralizing effect of an essential oil fluoride mouthrinse in an intraoral caries test. JADA 135:231-237, 2004.

Paes Leme AF, Machado Tabchoury CM, Zero DT, Cury JA. The effect of fluoride dentifrice and acidulated phosphate fluoride application on early artificial carious lesions. Am J Dent 16:91-95, 2003. 

Fontana M, Gonzalez-Cabezas C, Wilson ME, Stookey GK. Inhibition of secondary caries lesion progression using fluoride varnish. Caries Res, 36:129-135, 2002.

Zero D. Application of clinical models in remineralization research. J Clin Dent 10:74-85, 1999.

Gonzalez-Cabezas C, Fontana M, Dunipace AJ, Li Y, Fischer G, Proskin HM, & Stookey GK. Measurement of enamel remineralization using microradiography and confocal microscopy. A correlational study. Caries Res 32:385-392,1998.

Schemehorn, B.R., Wood, G.D. and Roberts, J.A.: Comparison of surface hardness and TMR results from an in-vitro remineralization model. Caries Res 30:4 (Abstract 19), 1996. 

Zero DT. In situ caries models.  Adv Dent Res 9:214-230, 1995.

Schemehorn, B.R., Wood, G.D. and Roberts, J.A.: An in-vitro Remin/Demin model showing a fluoride dose response. J. Dent. Res. 73:241 (Abstract 1117), 1994. 

Schemehorn, B.R., Farnham, R.L., Wood, G.D. and Stookey, G.K.: Fluoride uptake and remineralization in human and bovine enamel. J. Dent. Res., 71:186 (Abstract 644), 1992.

Featherstone JDB, Zero DT.  An in situ model for simultaneous assessment of inhibition of demineralization and enhancement of remineralization.  J Dent Res 71 (Spec Iss):804-810, 1992.