Metabolic Effects of Tobacco/
Dental Stain Formation

Examination of the effects of nicotine on cell:

• cytokines

• extracellular matrix

• adhesion

• viability

Examination of dental stain for the:

• specific organic and inorganic composition

• mechanism of formation

Program Director

Byron L. Olson, PhD

Other Faculty Supporting the Program

Dr. Richard Gregory, PhD
Dr. Jack Breen
Dr. Roger Roeske

Recent Publications

Zapata, C., Gregory, R., McDonald, J., and Olson, B.: Nicotine Effects on the Stimulation of Interleukins in Periodontal Fibroblasts. J. Dent. Res., 78, Abstract # 1322, 1999.

Schymik, M., Gregory, R., McDonald, J. and Olson, B.: Nicotine Effects on the Release of IL-6 from Epithelial Cells. J. Dent. Res., 78, Abstract # 1323, 1999.

Schymik, M., Gregory, R., McDonald, J. and Olson, B. Effects of Nicotine and IL-1B on Epithelial Cell IL-6 Release. J. Dent. Res., 79, p. 317, Abstract # 1389, 2000.

Zapata, C., Gregory R., McDonald, J. and Olson, B. Long-term Nicotine Affects Stimulation of IL-6 in Periodontal Fibroblasts. J. Dent., Res., 80; 172 Abstract # 1095, 2001.

Zhang, Z., Gregory, R. and Olson, B. Nicotine Effects on T Cell Proliferation and Interleukin-6 Production. J. Dent. Res., 81; A129, abstract # 862, 2002.

Brady, R., Gregory, R., and Olson, B. Nicotine effects on fibroblast proliferation and interleukin-8 release. J. Dent. Res., 82; b 294, abstract #2269, 2003.

Zhang, Z., Gregory, R., and Olson, B. Nicotine and mitogen effects on T-cell interleukin-6 release. J. Dent. Res., 83: Abstract # 2436, 2004.