Innate Immunity
in Oral Pathology

Investigate the role of toll like receptors in oral and paraoral soft tissue pathology.

Specific Objectives

• Comparative analysis of expression of members of the toll like receptor (TLR) family in mucosa from different sites of the oral cavity.

• Correlate the expression pattern of TLRs with local microbial ecosystem.

• Investigate the expression of TLRs in fluid and cellular component saliva.

• Evaluate the correlation between TLR expression patterns in saliva, oral mucosa and the local microbiota.

Program Director

Dr. Mythily Srinivasan

Other Faculty Supporting the Program

Dr. Susan Zunt
Dr. Rajaraman Eri

Licensing and sponsored research opportunities abstract: CD80 Binding Functional Pseudoreceptor

Licensing and sponsored research opportunities contact Mark Reichel

For research collaboration contact Dr. Srinivasan

Relevant Publications

Zunt SL.  Recurrent aphthous stomatitis.  Dermatologic Clinics of North America.  2003: 21:33-39.

Zunt, SL.  Disorders of the Mucous Membranes.  Chapter in Pathology of the Skin, 2 ed., Farmer Evan R. and Antoinette F. Hood, editors, 1999.

Zunt SL. 2000.Oral Candidiasis: Diagnosis and Treatment, The Journal of Practical Hygiene  9(5): 31-36.

Zunt, S. L.:1996.The Oral Manifestations of Vesiculobullous Diseases.  Dermatologic Clinics of North America 14:291-302.

Srinivasan M, Hazarey VK. 1991. Role of Anxiety in Oral Lichen Planus: Dental Dialogue 3, 16-19.

Srinivasan M, Jewell SD. 2001. Quantitative estimation of PCNA, c-myc, EGFR and TGF-a in oral submucous fibrosis – An immunohistochemical study. Oral Oncology 37, 61-67.

Srinivasan M, Jewell SD.2001. Evaluation of TGF-a And EGFR Expression In Oral Leukoplakia And Oral Submucous Fibrosis By Quantitative Immunohistochemistry. Oncology, 61 (4) 284-92.

Srinivasan M, Sedmak D, Jewell SD. (2002). Molecular quality of tissues for research- an overview for Prospective Investigators. American Journal of Pathology, 161 (6) 1961-71.

Cohen DM, Bhattacharyya I, Zunt, SL and Tomich CE.  Linear IgA disease histologically and clinically masquerading as lichen planus.  Oral Surg Oral Med Oral Pathol Oral Radiol Endod 1999: (88),196-210.

Rajaraman Eri, Julie Johnsson, Livia Keleman and Graham Radford-Smith (2004), A role for CCR5 ▲32 mutation in the development of primary sclerosing cholangitis. Genes and Immunity.5: 444-450.