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Dr. Jack Windsor
NAME:  L. Jack Windsor, Ph.D.
PHONE:  (317) 274-1448
FAX:  (317) 278-1411
E-MAIL:  ljwindso@iupui.edu

OFFICE ADDRESS: 
Indiana University School of Dentistry
Department of Oral Biology
1121 W. Michigan Street, Room  271
Indianapolis, Indiana 46202

POSITION/TITLE:
Associate Professor of Oral Biology
Adjunct Associate Professor of Anatomy,
School of Medicine


RESEARCH INTEREST

Research centers on the elucidation of the mechanism's by which cells degrade the extracellular matrix in healthy and diseased tissues.  It is focused largely on a group of zinc-dependent endopeptidases known as the matrix metalloproteinases (MMPs).  Collectively, these enzymes are capable of cleaving most of the major components of the extracellular matrix and are believed to be some of the tools by which cells facilitate the destruction of the extracellular matrix.

Click here to visit Dept. of Oral Biology research interests.

STUDENTS INVOLVED IN RESEARCH:

Dr. Windsor's lab (Left to Right): M. Ellis, C. Chandrakeerthi, J. Windsor, K. Wisithphrom, F. Song, J. Zhou.

RECENT PUBLICATIONS

1. Wisithphrom, K. and Windsor, L.J. 2006. Interleukin-1a alters the expression of matrix metalloproteinases and the collagen degradation by pulp fibroblasts. J. Endod. --32: 186-192.
2. Zhou, J. and Windsor, L.J. 2006. Porphyromonas gingivalis affects host collagen degradation by affecting expression, activation, and inhibition of matrix metalloproteinases. J. Periodont. Res. 41: 47-54.
3. Song, F. and Windsor, L. J. 2005.  Non-Matrix Metalloproteinases (MMP) Mediated Collagen Degradation, Biochim. Biophys. Acta, 1721: 65-72.
4. Murray, P. E., Windsor, L. J., Hafez, A. A., Stevenson, R. G., and Cox, C. F.  2003.   Comparison of pulp capping responses to composite resins,  Op. Dent.. 28: 242-250.
5. Murray, P. E., Smith, A. J., Windsor, L. J., and Mjör, I. A.  2003.   Remaining dentin thickness and human pulp responses.  Intern.  Endo. J.   36(1): 33-43.
6. Murray, P. E., About, I. A., Franquin, J-C., and Windsor, L. J.  2003.   Odontoblast morphology and dental repair.  J. Dent.  31: 75-82 .
7. Behzadian, M. A., Windsor, L. J., Ghaly, N., Liou, G., Tsai, N., and Caldwell, R. B.:   2003.  VEGF-induced paracellular permeability in cultured endothelial cells involves urokinase and its receptor.  FASEB J.  17: 752-754.
8. Murray, P.E., Hafez, A.A., Smith, A.J., Windsor. L.J., and Cox, C.F.  2003.  Histomorphometric analysis of odontoblast-like cell numbers and dentine bridge secretory aactivity following pulp explsure.  Intern. Endo. J.  36:(2):  106-116.
9. Murray, P.E., Kitasako, Y., Windsor. L.J., Tagami, J., and Smith, A.J.  2002.  Hierarchy of variables correlated to odontoblast-like cell numbers following pulp capping.  J. Dent.  30: 297-304.
10. Murray, P. E., Hafez, A. A., Windsor, L. J., Smith, A. J., and Cox, C. F.  2002.  Comparison of pulp responses following restoration of exposed and unexposed cavities. J. Dent.  30: 213-222.
11. Murray, P. E., Windsor, L. J., Smyth, T. W., Hafez, A. A., and Cox, C. F.  2002.  Analysis of pulp capping reactions to restorative procedures, materials, pulp capping, and future therapies.  Criti. Rev. Oral Biol. Med.. 13: 509-520.
12. Hantke, B., Lahmann, C., Venzke, K., Fischer, T., Kocourek, A., Windsor, L. J., Bergemann, J., Stab, F., and Tschesche, H.  2002.  .Influence of Flavonoids and Vitamins on the MMP- and TIMP-expression of Human Dermal Fibroblasts after UVA Irradiation.  J. Photochem. Photobiol. Sci, 1:  826-833.
13. Windsor, L. J., Havemose-Poulsen, A., Yamada, S., Lyons, J. G., Birkedal-Hansen-Hansen, B., Stetler-Stevenson, W., and Birkedal-Hansen, H.: Matrix Metalloproteinases, Current Protocols in Cell Biology, Supplement 13, Unit 10.8, 2002.
14. Behzadian, M.A., Wang, X., Windsor, L.J., ghaly, N., and Caldwell, R.B.:  2001.  TGF-ß Increases Retinal Endothelial Cell Permeability by Increasing MMP-9, Possible Role of Glial Cells in Endothelial Barrier Function.  Invest. Ophthalmol. Vis. Sci. 42:853-859.
15. Aznavoorian, S., Moore, B.A., Alexander, L.D., Hallit, S., Windsor, L.J., and Engler, J.A.  2001.    Membrane Type I-Matrix metalloproteinase mediated degradation of Type I collagen by oral squamous cell carcinoma.   Cancer Res. 61:6264-6275.
16. Saghizadeh, M., Brown, D.J., Castellon, R., Chwa, M., Huang, G.H., Ljubimova, J.Y., Rosenberg, S., Spirin, K.S., Stolitenko, R.B., Adachi, W., Kinoshita, S., Murphy, G., Windsor, L.J., Kenney, M.C., and Ljubimov, A.V.  2001.  Overexpression of MMP-10 and MMP-3 in human diabetic corneas: A possible mechanism of basement membrane and integrin alterations.  Am. J. Pathol.  158:723-734.
17. Moore, B.A., Arnavoorian, S., Engler, J.A., and Windsor, L.J.  2000.  Induction of  collagenase-3 (MMP-13) in rheumatoid arthritis synovial fibroblasts.  Biochim.  Biophys. Acta.  1502:307-318.
18. Steele, D.L., El-Kabbani, O., Dunten, P., Windsor, L.J., Kammlott, R.U., Crowther, R. LC., Michoud, C., Engler, J.A., and Birktoft, J.J.  2000.  Expression, characterization, and structure determination of an active site mutant (Glu202-Gln) of mini-stromelysin-1.  Prot. Engineer. 13(6):397-405
19. Windsor, L.J. and Steele, D.L.  2000.  Expression of recombinant matrix metalloproteinases in Escherichia coli.  Methods in Mol. Biol. 151:191-205.
20. Pickett, K.L., Harber, G.J., DeCarlo, A.A., Louis, P., Shaneyfelt, S., Windsor, L.J., and   Bodden,  M.K.  1999.   92K-GL (MMP-9) and 72K-GL (MMP-2) are produced in vivo by  human oral squamous cell carcinomas and can enhance fib-CL (MMP-1) activity in vitro.  J. Dent. Res. 78:1354-1361.
21. Pickett, K.L., Harber, G.J., DeCarlo, A.A., Louis, P., Shaneyfelt, S., Windsor, L.J., and   Bodden,  M.K.  1999.   92K-GL (MMP-9) and 72K-GL (MMP-2) are produced in vivo by  human oral squamous cell carcinomas and can enhance fib-CL (MMP-1) activity in vitro.  J. Dent. Res. 78:1354-1361.
22. Galazka, G., Windsor, L.J., Birkedal-Hansen, H., and Engler, J.A.  1999.  Spontaneous propeptide processing of mini-SL-1 mutants blocked by APMA (4-aminophenylmercuric acetate).  Biochem. 38:1316-1322.
23. Qin, H., Moellinger, J.D., Wells, A., Windsor, L.J., Sun, Y., and Benveniste, E.N.  1998.  Transcriptional  suppression of  matrix metalloproteinase-2 gene expression in human astroglioma cells by TNF-a and  IFN-γ.  J. Immunol.  161: 6664-6673.
24. DeCarlo Jr., A.A., Grenett, H.E., Harber, G.J., Windsor, L.J., Bodden, M.K., Birkedal-Hansen, B., and Birkedal-Hansen, H.  1998.  Induction of matrix  metalloproteinases and a collagen-degrading phenotype in fibroblasts and epithelial cells by secreted Porphyromonas gingivalis proteinase.  J. Peridont. Res.  33: 408-420.
25. Caterina, N.C.M., Windsor, L.J., Bodden, M.K., Yermovsky, A.E., Birkedal-Hansen, H., and Engler, JA. 1998.  Glycosylation and NH2-terminal mutants of the tissue inhibitor of metalloproteinases (TIMP-1).  Biochim. Biophys. Acta.  1388: 21-34.
26. Birkedal-Hansen, H., Bodden, M.K., Caterina, N.C.M., Windsor, L.J., Netzel-Arnett, S., and Engler, J.A. 1998.  In:   Inhibitors of Metalloproteinases in Development and Disease.  Hawkes, S.P., Edwards, D.R., and Khokha, R. (Eds.) Harwood Acaedemic Publishing, Lausanne, Switzerland.
27. Birkedal-Hansen, H., Bodden, M.K., Caterina, N.C.M., Windsor, L.J., Netzel-Arnett, S., and Engler, J.A. 1998.  In:   Inhibitors of Metalloproteinases in Development and Disease.  Hawkes, S.P., Edwards, D.R., and Khokha, R. (Eds.) Harwood Acaedemic Publishing, Lausanne, Switzerland.
1121 West Michigan St. | Indianapolis, IN 46202 | Tel. 317-274-7957 | Fax 317-274-2419 | Patient Fax 317-278-6958
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